Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon.

ABSTRACT: The NLRP3 inflammasome coordinates inflammation in response to different pathogen- and damage-associated molecular patterns, being implicated in different infectious, chronic inflammatory, metabolic and degenerative diseases. In chronic tendinopathic lesions, different non-resolving mechanisms produce a degenerative condition that impairs tissue healing and which therefore complicates their clinical management. Percutaneous needle electrolysis consists of the application of a galvanic current and is an emerging treatment for tendinopathies. In the present study, we found that galvanic current activates the NLRP3 inflammasome and induces an inflammatory response that promotes a collagen-mediated regeneration of the tendon in mice. This study establishes the molecular mechanism of percutaneo

SUBMITTER: Penin-Franch A 

PROVIDER: S-EPMC8896827 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature