Platinum-copper alloy nanoparticles armored with chloride ion transporter to promote electro-driven tumor inhibition.

ABSTRACT: The induction of oxidative species, driven by oscillating electric field (E), has recently emerged as an effective approach for tumor inhibition, so-called electrodynamic therapy (EDT). While it offers a series of advantages attracting considerable attention, the fundamental mechanism and improvement strategies for EDT approach are being endeavored extensively with the aid of new material explorations. An interesting phenomenon observed in early studies is that the on-site concentration of chloride ion is highly favored for the induction of oxidative species and the efficacy of tumor inhibition. Following this discovery ignored previously, here for the first time, fine Pt/Cu alloy nanoparticles (PtCu₃ NPs) are integrated with chloride ion transporter (CIT) for EDT-based combinat

SUBMITTER: Chen T 

PROVIDER: S-EPMC8897047 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature