MiR-378a inhibits glucose metabolism by suppressing GLUT1 in prostate cancer.

ABSTRACT: Prostate cancer (PCa) is the fifth leading cause of cancer related deaths worldwide, in part due to a lack of molecular stratification tools that can distinguish primary tumours that will remain indolent from those that will metastasise. Amongst potential molecular biomarkers, microRNAs (miRs) have attracted particular interest because of their high stability in body fluids and fixed tissues. These small non-coding RNAs modulate several physiological and pathological processes, including cancer progression. Herein we explore the prognostic potential and the functional role of miRs in localised PCa and their relation to nodal metastasis. We define a 7-miR signature that is associated with poor survival independently of age, Gleason score, pathological T state, N stage and surgical margin st

SUBMITTER: Cannistraci A 

PROVIDER: S-EPMC8897193 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature