Intrauterine drug exposure as a risk factor for cerebral palsy.

ABSTRACT:

Aim

To determine whether infants with intrauterine drug exposure (IUDE) are similarly at risk for cerebral palsy (CP) as other high-risk populations, whether CP classification differs based on IUDE status, and describe the association of CP with specific substances among exposed infants.

Method

This was a retrospective analysis of infants in a high-risk follow-up program (n=5578) between January 2014 and February 2018 with a history of IUDE or who received a CP diagnosis. CP rates were compared using two-sample z-tests. CP classification was assessed using Fisher's exact, Cochran-Armitage, and Wilcoxon rank-sum tests. Models for CP risk were assessed using multivariable logistic regression.

Results

Among all infants with IUDE (n=1086), 53.8% were male with a mean (SD)

SUBMITTER: Benninger KL 

PROVIDER: S-EPMC8897226 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature