Younger age and early puberty are associated with cognitive function decline in children with Cushing disease.

ABSTRACT:

Objective

To investigate the effect of hypercortisolism on the developing brain we performed clinical, cognitive, and psychological evaluation of children with Cushing disease (CD) at diagnosis and 1 year after remission.

Study design

Prospective study of 41 children with CD. Children completed diverse sets of cognitive measures before and 1 year after remission. Neuropsychological evaluation included the Wechsler Intelligence Scale, California Verbal Learning Test, Trail Making Test, the combined subset scores of Wide Range Achievement Test and Woodcock-Johnson Psychoeducational Battery Test of Achievement, and the Behavioral Assessment System for Children.

Results

Comprehensive cognitive evaluations at baseline and 1 year following cure revealed significant decline

SUBMITTER: Keil MF 

PROVIDER: S-EPMC8897227 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature