Identification of phenotypes in paediatric patients with acute respiratory distress syndrome: a latent class analysis.

ABSTRACT:

Background

Previous latent class analysis of adults with acute respiratory distress syndrome (ARDS) identified two phenotypes, distinguished by the degree of inflammation. We aimed to identify phenotypes in children with ARDS in whom developmental differences might be important, using a latent class analysis approach similar to that used in adults.

Methods

This study was a secondary analysis of data aggregated from the Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) clinical trial and the Genetic Variation and Biomarkers in Children with Acute Lung Injury (BALI) ancillary study. We used latent class analysis, which included demographic, clinical, and plasma biomarker variables, to identify paediatric ARDS (PARDS) phenotypes within a cohort of ch

SUBMITTER: Dahmer MK 

PROVIDER: S-EPMC8897230 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature