Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions.

ABSTRACT: Breathing can be heavily influenced by pain or internal emotional states, but the neural circuitry underlying this tight coordination is unknown. Here we report that Oprm1 (μ-opioid receptor)-expressing neurons in the lateral parabrachial nucleus (PBL) are crucial for coordinating breathing with affective pain in mice. Individual PBL^Oprm1 neuronal activity synchronizes with breathing rhythm and responds to noxious stimuli. Manipulating PBL^Oprm1 activity directly changes breathing rate, affective pain perception, and anxiety. Furthermore, PBL^Oprm1 neurons constitute two distinct subpopulations in a "core-shell" configuration that divergently projects to the forebrain and hindbrain. Through non-overlapping projections to the central amygdala and pre-Bötzinger

SUBMITTER: Liu S 

PROVIDER: S-EPMC8897232 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature