Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure.

ABSTRACT:

Background

Abnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to contractile dysfunction, but their role, if any, in HF-related pathologic remodeling is much less established. CK (creatine kinase), the primary muscle energy reserve reaction which rapidly provides ATP at the myofibrils and regenerates mitochondrial ADP, is down-regulated in experimental and human HF. We tested the hypotheses that pathologic remodeling in human HF is related to impaired cardiac CK energy metabolism and that rescuing CK attenuates maladaptive hypertrophy in experimental HF.

Methods

First, in 27 HF patients and 14 healthy subjects, we measured cardiac energetics and left ventricular remodeling using noninvasive magnetic resonance ³¹P spectroscopy and

SUBMITTER: Keceli G 

PROVIDER: S-EPMC8897235 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature