Local feedback inhibition tightly controls rapid formation of hippocampal place fields.

ABSTRACT: Hippocampal place cells underlie spatial navigation and memory. Remarkably, CA1 pyramidal neurons can form new place fields within a single trial by undergoing rapid plasticity. However, local feedback circuits likely restrict the rapid recruitment of individual neurons into ensemble representations. This interaction between circuit dynamics and rapid feature coding remains unexplored. Here, we developed "all-optical" approaches combining novel optogenetic induction of rapidly forming place fields with 2-photon activity imaging during spatial navigation in mice. We find that induction efficacy depends strongly on the density of co-activated neurons. Place fields can be reliably induced in single cells, but induction fails during co-activation of larger subpopulations due to local circuit c

SUBMITTER: Rolotti SV 

PROVIDER: S-EPMC8897257 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature