Observational learning promotes hippocampal remote awake replay toward future reward locations.

ABSTRACT: The neural circuit mechanisms underlying observational learning, learning through observing the behavior of others, are poorly understood. Hippocampal place cells are important for spatial learning, and awake replay of place cell patterns is involved in spatial decisions. Here we show that, in observer rats learning to run a maze by watching a demonstrator's spatial trajectories from a separate nearby observation box, place cell patterns during self-running in the maze are replayed remotely in the box. The contents of the remote awake replay preferentially target the maze's reward sites from both forward and reverse replay directions and reflect the observer's future correct trajectories in the maze. In contrast, under control conditions without a demonstrator, the remote replay is signifi

SUBMITTER: Mou X 

PROVIDER: S-EPMC8897267 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature