Contribution of the caudal medullary raphe to opioid induced respiratory depression.

ABSTRACT:

Background

Opioid-induced respiratory depression can be partially antagonized in the preBötzinger Complex and Parabrachial Nucleus/Kölliker-Fuse Complex. We hypothesized that additional opioid antagonism in the caudal medullary raphe completely reverses the opioid effect.

Methods

In adult ventilated, vagotomized, decerebrate rabbits, we administrated remifentanil intravenously at "analgesic", "apneic", and "very high" doses and determined the reversal with sequential naloxone microinjections into the bilateral Parabrachial Nucleus/Kölliker-Fuse Complex, preBötzinger Complex, and caudal medullary raphe. In separate animals, we injected opioid antagonists into the raphe without intravenous remifentanil.

Results

Sequential naloxone microinjections completely reversed res

SUBMITTER: Palkovic B 

PROVIDER: S-EPMC8897277 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature