Kidney Function, Kidney Replacement Therapy, and Mortality in Men and Women.

ABSTRACT:

Introduction

Women are more likely to have chronic kidney disease (CKD), compared with men, yet they are less likely to receive dialysis. Whether this sex disparity, which has predominantly been observed in nephrology-referred or CKD-specific cohorts so far, has a biological root cause remains unclear.

Methods

We extracted general population data from the Stockholm CREAtinine Measurements project (SCREAM) (N = 496,097 participants, 45.5% men, 54.5% women). We used Cox regression to model male-to-female cause-specific hazard ratios (csHRs) for the competing events kidney replacement therapy (KRT, by dialysis or transplantation) and pre-KRT death, adjusted for baseline age, baseline kidney function (assessed via estimated glomerular filtration rate [eGFR] and eGFR slope

SUBMITTER: Hodlmoser S 

PROVIDER: S-EPMC8897304 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature