Enhanced pro-apoptosis gene signature following the activation of TAp63α in oocytes upon γ irradiation.

ABSTRACT: Specialized surveillance mechanisms are essential to maintain the genetic integrity of germ cells, which are not only the source of all somatic cells but also of the germ cells of the next generation. DNA damage and chromosomal aberrations are, therefore, not only detrimental for the individual but affect the entire species. In oocytes, the surveillance of the structural integrity of the DNA is maintained by the p53 family member TAp63α. The TAp63α protein is highly expressed in a closed and inactive state and gets activated to the open conformation upon the detection of DNA damage, in particular DNA double-strand breaks. To understand the cellular response to DNA damage that leads to the TAp63α triggered oocyte death we have investigated the RNA transcriptome of oocytes following irradiat

SUBMITTER: Fester N 

PROVIDER: S-EPMC8897389 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature