Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease.

ABSTRACT: Cumulative evidence over the last decades have supported the role of gum infections as a risk for future major cardiovascular events. The precise mechanism connecting coronary artery disease (CAD) with periodontal findings has remained elusive. Here, we employ next generation phage display mimotope-variation analysis (MVA) to identify the features of dysfunctional immune system that associate CAD with periodontitis. We identify a fine molecular description of the antigenic epitope repertoires of CAD and its most severe form - acute coronary syndrome (ACS) by profiling the antibody reactivity in a patient cohort with invasive heart examination and complete clinical oral assessment. Specifically, we identify a strong immune response to an EBV VP26 epitope mimicking multiple antigens of oral

SUBMITTER: Jaago M 

PROVIDER: S-EPMC8897497 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature