Meta-analysis of ICU Delirium Biomarkers and Their Alignment With the NIA-AA Research Framework.

ABSTRACT:

Background

Between 30% and 80% of survivors of critical illness experience cognitive impairment, but the underlying mechanisms remain unknown.

Objective

To determine whether intensive care unit (ICU) delirium biomarkers align with the National Institute on Aging-Alzheimer's Association (NIA-AA) research framework for diagnostic biomarkers for Alzheimer disease and other related dementias (ADRD).

Methods

Ovid MEDLINE, PsycInfo, Embase, and the Cochrane Library were systematically searched for articles published between January 1, 2000, and February 20, 2020, on the relationship between delirium and biomarkers listed in the NIA-AA framework. Only studies that addressed delirium in the ICU setting and fluid biomarkers were included in these analyses.

Results

Of 61

SUBMITTER: Chan CK 

PROVIDER: S-EPMC8897570 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature