The transplantation of particulated juvenile allograft cartilage and synovium for the repair of meniscal defect in a lapine model.

ABSTRACT:

Background

Synovium has been confirmed to be the primary contributor to meniscal repair. Particulated Juvenile Allograft Cartilage (PJAC) has demonstrated promising clinical effect on repairing cartilage. The synergistic effect of synovium and PJAC transplant on meniscal fibrocartilaginous repair is unclear. We hypothesize that the transplantation of synovium and PJAC synergistically facilitates meniscal regeneration and the donor cells within graft tissues still survive in the regenerated tissue at the last follow up (16 weeks postoperatively).

Methods

The study included 24 mature female rabbits, which were randomly divided into experimental and control groups. A cylindrical full-thickness defect measuring 2.0 ​mm was prepared in the avascular portion of the anterior horn o

SUBMITTER: Yan W 

PROVIDER: S-EPMC8897607 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature