Impact of different white matter hyperintensities patterns on cognition: A cross-sectional and longitudinal study.

ABSTRACT:

Objectives

White matter hyperintensities (WMH) are highly prevalent in older adults and considered to be a contributor to cognition impairment. However, the strategic WMH lesion distribution related to cognitive impairment is still debated. The aim of this study was to characterize the spatial patterns of WMH associated with cognitive impairment and explore its risk factors.

Methods

We retrospectively analyzed patients who underwent T2 fluid attenuated inversion recovery (FLAIR) and mini-mental state examination (MMSE) in two centers. WHM was classified into four patterns based on T2 FLAIR as follows: (1) multiple subcortical spots (multi-spots); (2) peri-basal ganglia (peri-BG); (3) anterior subcortical patches (anterior SC patches); and (4) posterior subcortical patches (p

SUBMITTER: Wang J 

PROVIDER: S-EPMC8897653 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature