Neural correlates of working memory and its association with metabolic parameters in early-treated adults with phenylketonuria.

ABSTRACT:

Background

Phenylketonuria (PKU) is an inborn error of metabolism affecting the conversion of phenylalanine (Phe) into tyrosine. Previous research has found cognitive and functional brain alterations in individuals with PKU even if treated early. However, little is known about working memory processing and its association with task performance and metabolic parameters. The aim of the present study was to examine neural correlates of working memory and its association with metabolic parameters in early-treated adults with PKU.

Methods

This cross-sectional study included 20 early-treated adults with PKU (mean age: 31.4 years ± 9.0) and 40 healthy controls with comparable age, sex, and education (mean age: 29.8 years ± 8.2). All participants underwent functional magnetic resona

SUBMITTER: Abgottspon S 

PROVIDER: S-EPMC8897706 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature