Neurofeedback-guided kinesthetic motor imagery training in Parkinson's disease: Randomized trial.

ABSTRACT:

Background

Parkinson's disease (PD) causes difficulty with maintaining the speed, size, and vigor of movements, especially when they are internally generated. We previously proposed that the insula is important in motivating intentional movement via its connections with the dorsomedial frontal cortex (dmFC). We demonstrated that subjects with PD can increase the right insula-dmFC functional connectivity using fMRI-based neurofeedback (NF) combined with kinesthetic motor imagery (MI). The current study is a randomized clinical trial testing whether NF-guided kinesthetic MI training can improve motor performance and increase task-based and resting-state right insula-dmFC functional connectivity in subjects with PD.

Methods

We assigned nondemented subjects with mild PD (Hoehn &

SUBMITTER: Tinaz S 

PROVIDER: S-EPMC8897714 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature