Integrin β3 in forebrain Emx1-expressing cells regulates repetitive self-grooming and sociability in mice.

ABSTRACT:

Background

Autism spectrum disorder (ASD) is characterized by repetitive behaviors, deficits in communication, and overall impaired social interaction. Of all the integrin subunit mutations, mutations in integrin β3 (Itgb3) may be the most closely associated with ASD. Integrin β3 is required for normal structural plasticity of dendrites and synapses specifically in excitatory cortical and hippocampal circuitry. However, the behavioral consequences of Itgb3 function in the forebrain have not been assessed. We tested the hypothesis that behaviors that are typically abnormal in ASD-such as self-grooming and sociability behaviors-are disrupted with conditional Itgb3 loss of function in forebrain circuitry in male and female mice.

Methods

We generated male and female conditional

SUBMITTER: Lopuch AJ 

PROVIDER: S-EPMC8897866 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature