Lung damage created by high tidal volume ventilation in rats with monocrotaline-induced pulmonary hypertension.

ABSTRACT:

Background

Rats with chronic hypoxia-induced non-inflammatory pulmonary hypertension (PH) are resistant to ventilator-induced lung injury. We investigated the effect of high tidal volume ventilation in another model of PH, monocrotaline (MCT)-induced PH, which is a type of inflammatory PH.

Methods

PH was induced in rats by subcutaneous injection with 60 mg/kg MCT. Normal control rats, rats at 2 weeks after MCT injection (MCT2), and rats at 3 weeks after MCT injection (MCT3) were ventilated with low tidal volume (LV, 6 mL/kg) or high tidal volume (HV, 35 mL/kg) for 2 h with room air without positive end-expiratory pressure. Arterial oxygen pressure (PaO₂) and Evans blue dye (EBD) extravasation were measured. Hypertensive pulmonary vascular remodeling was assessed m

SUBMITTER: Kawai M 

PROVIDER: S-EPMC8897872 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature