Transcriptomics and metabolomics of engineered Synechococcus elongatus during photomixotrophic growth.

ABSTRACT:

Background

Converting carbon dioxide (CO₂) into value-added chemicals using engineered cyanobacteria is a promising strategy to tackle the global warming and energy shortage issues. However, most cyanobacteria are autotrophic and use CO₂ as a sole carbon source, which makes it hard to compete with heterotrophic hosts in either growth or productivity. One strategy to overcome this bottleneck is to introduce sugar utilization pathways to enable photomixotrophic growth with CO₂ and sugar (e.g., glucose and xylose). Advances in engineering mixotrophic cyanobacteria have been obtained, while a systematic interrogation of these engineered strains is missing. This work aimed to fill the gap at omics level.

Results

We first constructed two engineered

SUBMITTER: Tan LR 

PROVIDER: S-EPMC8897908 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature