Lamellipodia-like protrusions and focal adhesions contribute to collective cell migration in zebrafish.

ABSTRACT: Collective cell migration is a process where cohorts of cells exhibit coordinated migratory behavior. During individual and collective cellular migration, cells must extend protrusions to interact with the extracellular environment, sense chemotactic cues, and act as points of attachment. The mechanisms and regulators of protrusive behavior have been widely studied in individually migrating cells; however, how this behavior is regulated throughout collectives is not well understood. To address this, we used the zebrafish posterior lateral line primordium (pLLP) as a model. The pLLP is a cluster of ~150 ​cells that migrates along the zebrafish trunk, depositing groups of cells that will become sensory organs. To define protrusive behavior, we performed mosaic analysis to sparsely label pLLP

SUBMITTER: Olson HM 

PROVIDER: S-EPMC8898079 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature