Novel Δ⁸-Tetrahydrocannabinol Vaporizers Contain Unlabeled Adulterants, Unintended Byproducts of Chemical Synthesis, and Heavy Metals.

ABSTRACT: Cannabis e-cigarettes containing Δ⁸-tetrahydrocannabinol (Δ⁸-THC) produced synthetically from hemp-derived cannabidiol (CBD) have recently risen in popularity as a legal means of cannabis consumption, but questions surrounding purity and unlabeled additives have created doubts of their safety. Herein, NMR, GC-MS, and ICP-MS were used to analyze major components of 27 products from 10 brands, and it was determined none of these had accurate Δ⁸-THC labeling, 11 had unlabeled cutting agents, and all contained reaction side-products including olivetol, Δ⁴⁽⁸⁾-iso-tetrahydrocannabinol, 9-ethoxyhexahydrocannabinol, Δ⁹-tetrahydrocannabinol (Δ⁹-THC), heavy metals, and a novel previously undescribed cannabinoid, iso-tetr

SUBMITTER: Meehan-Atrash J 

PROVIDER: S-EPMC8898185 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature