Associations of systemic health and medication use with the enlargement rate of geographic atrophy in age-related macular degeneration.

ABSTRACT:

Background

The associations of geographic atrophy (GA) progression with systemic health status and medication use are unclear.

Methods

We manually delineated GA in 318 eyes in the Age-Related Eye Disease Study. We calculated GA perimeter-adjusted growth rate as the ratio between GA area growth rate and mean GA perimeter between the first and last visit for each eye (mean follow-up=5.3 years). Patients' history of systemic health and medications was collected through questionnaires administered at study enrolment. We evaluated the associations between GA perimeter-adjusted growth rate and 27 systemic health factors using univariable and multivariable linear mixed-effects regression models.

Results

In the univariable model, GA perimeter-adjusted growth rate was associat

SUBMITTER: Shen LL 

PROVIDER: S-EPMC8898317 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature