A Comprehensive Review of Vagus Nerve Stimulation for Depression.

ABSTRACT:

Objectives

Vagus nerve stimulation (VNS) is reemerging as an exciting form of brain stimulation, due in part to the development of its noninvasive counterpart transcutaneous auricular VNS. As the field grows, it is important to understand where VNS emerged from, including its history and the studies that were conducted over the past four decades. Here, we offer a comprehensive review of the history of VNS in the treatment of major depression.

Materials and methods

Using PubMed, we reviewed the history of VNS and aggregated the literature into a narrative review of four key VNS epochs: 1) early invention and development of VNS, 2) path to Food and Drug Administration (FDA) approval for depression, 3) refinement of VNS treatment parameters, and 4) neuroimaging of VNS.

Resul

SUBMITTER: Austelle CW 

PROVIDER: S-EPMC8898319 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature