Energy deprivation-induced AMPK activation inhibits milk synthesis by targeting PrlR and PGC-1α.

ABSTRACT:

Background

The mammary gland is responsible for milk production and secretion, which is critical for neonatal health during lactation. Lactation efficiency is largely affected by energy status with unclear mechanism.

Results

In the current study, we found that synthesis of milk fat and protein was significantly inhibited under energy-deficient conditions, which is accompanied with AMP-activated protein kinase (AMPK) activation. Modulating the AMPK signaling pathway directly or indirectly affects the synthesis of milk fat and protein. Besides mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of milk synthesis, we discovered that AMPK mainly regulates the synthesis of milk protein through prolactin signaling. Mechanistically, AMPK triggers the ubiqui

SUBMITTER: Wu Z 

PROVIDER: S-EPMC8898430 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature