Exposure to two-dimensional ultrathin Ti₃C₂ (MXene) nanosheets during early pregnancy impairs neurodevelopment of offspring in mice.

ABSTRACT:

Background

Two-dimensional ultrathin Ti₃C₂ (MXene) nanosheets have been extensively explored for various biomedical applications. However, safety issues and the effects of Ti₃C₂ on human health remain poorly understood.

Results

To explore the influence on foetal or offspring after exposure to Ti₃C₂ nanosheets, we established a mouse model exposed to different doses of Ti₃C₂ nanosheets during early pregnancy in this study. We found that Ti₃C₂ nanosheets had negligible effect on the reproductive ability of maternal mice, including average pregnancy days, number of new-borns, and neonatal weight, etc. Unexpectedly, abnormal neurobehavior and pathological changes in the

SUBMITTER: Wen Y 

PROVIDER: S-EPMC8898431 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature