In silico drug repositioning based on integrated drug targets and canonical correlation analysis.

ABSTRACT:

Background

Besides binding to proteins, the most recent advances in pharmacogenomics indicate drugs can regulate the expression of non-coding RNAs (ncRNAs). The polypharmacological feature in drugs enables us to find new uses for existing drugs (namely drug repositioning). However, current computational methods for drug repositioning mainly consider proteins as drug targets. Meanwhile, these methods identify only statistical relationships between drugs and diseases. They provide little information about how drug-disease associations are formed at the molecular target level.

Methods

Herein, we first comprehensively collect proteins and two categories of ncRNAs as drug targets from public databases to construct drug-target interactions. Experimentally confirmed drug-disease as

SUBMITTER: Chen H 

PROVIDER: S-EPMC8898485 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature