INHBA is a mediator of aggressive tumor behavior in HER2+ basal breast cancer.

ABSTRACT:

Background

Resistance to HER2-targeted therapeutics remains a significant clinical problem in HER2+ breast cancer patients with advanced disease. This may be particularly true for HER2+ patients with basal subtype disease, as recent evidence suggests they receive limited benefit from standard of care HER2-targeted therapies. Identification of drivers of resistance and aggressive disease that can be targeted clinically has the potential to impact patient outcomes.

Methods

We performed siRNA knockdown screens of genes differentially expressed between lapatinib-responsive and -resistant HER2+ breast cancer cells, which corresponded largely to luminal versus basal subtypes. We then validated hits in 2-d and 3-d cell culture systems.

Results

Knockdown of one of the genes,

SUBMITTER: Liu M 

PROVIDER: S-EPMC8898494 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature