Development of a protocol for maintaining viability while shipping organoid-derived retinal tissue.

ABSTRACT: Retinal organoid technology enables generation of an inexhaustible supply of three-dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications. The high similarity of organoid-derived retinal tissue and transplantable human fetal retina provides an opportunity for evaluating and modeling retinal tissue replacement strategies in relevant animal models in the effort to develop a functional retinal patch to restore vision in patients with profound blindness caused by retinal degeneration. Because of the complexity of this very promising approach requiring specialized stem cell and grafting techniques, the tasks of retinal tissue derivation and transplantation are frequently split between geographically distant teams. Delivery of delicate and per

SUBMITTER: Singh RK 

PROVIDER: S-EPMC8898623 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature