Immunotherapeutic Strategies in Chronic Lymphocytic Leukemia: Advances and Challenges.

ABSTRACT: Immune-based therapeutic strategies have drastically changed the landscape of hematological disorders, as they have introduced the concept of boosting immune responses against tumor cells. Anti-CD20 monoclonal antibodies have been the first form of immunotherapy successfully applied in the treatment of CLL, in the context of chemoimmunotherapy regimens. Since then, several immunotherapeutic approaches have been studied in CLL settings, with the aim of exploiting or eliciting anti-tumor immune responses against leukemia cells. Unfortunately, despite initial promising data, results from pilot clinical studies have not shown optimal results in terms of disease control - especially when immunotherapy was used individually - largely due to CLL-related immune dysfunctions hampering the achieveme

SUBMITTER: Perutelli F 

PROVIDER: S-EPMC8898826 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature