Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin.

ABSTRACT:

Objective

Polycystic ovary syndrome (PCOS) and hypothyroidism are related conditions, and both are associated with adverse pregnancy outcomes. Knowledge is lacking about the complex interaction between thyroid status and PCOS during pregnancy. We investigated the thyroid status and its association with pregnancy complications in PCOS, and in relation to metformin treatment.

Design

Post-hoc analyses of two randomized, double-blind, placebo-controlled trials.

Methods

288 pregnant women with PCOS were randomized to treatment with metformin or placebo from first trimester to delivery. We measured serum levels of thyroid stimulating hormone (TSH) and free thyroxine (fT4) at gestational week (gw) 5-12, 19, 32 and 36 and related to metformin treatment and pregnancy co

SUBMITTER: Trouva A 

PROVIDER: S-EPMC8898827 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature