CLCF1 Is a Novel Potential Immune-Related Target With Predictive Value for Prognosis and Immunotherapy Response in Glioma.

ABSTRACT:

Background

Cardiotrophin-like cytokine factor 1 (CLCF1) has been described as an oncogene and a potential therapeutic target in a variety of cancers, but its role in glioma remains unknown.

Methods

Based on The Cancer Genome Atlas (TCGA), we conducted a bioinformatics analysis to investigate the clinical significance and biological functions of CLCF1 in glioma at the transcriptional level and predicted the response to immunotherapy of glioma patients with different CLCF1 expression levels. All the results were further verified in Chinese Glioma Genome Altas(CGGA) Data processing and figure generating were performed with R language.

Results

Elevated CLCF1 expression was common in cancers and usually predicted poor prognosis, which was also consistent with gliomas. In U

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC8898905 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature