Various Subtypes of EGFR Mutations in Patients With NSCLC Define Genetic, Immunologic Diversity and Possess Different Prognostic Biomarkers.

ABSTRACT: Based on data analysis of 9649 Chinese primary NSCLC patients, we calculated the exact proportion of EGFR subtypes in NSCLC and evaluated the TMB level, PD-L1 expression level and tumor immune microenvironment among different EGFR mutation subtypes. Postoperative follow-up data for 98 patients were collected and analyzed. The results showed that several uncommon EGFR mutation subtypes have a higher proportion of TMB-high or strong positive PD-L1 expression than the total EGFR mutation group. In addition, different subtypes have different characteristics related to the immune microenvironment, such as G719 mutations being associated with more CD8⁺ T cell infiltration into tumors; except for EGFR 19del, CD8⁺ T cell infiltration into tumors of other EGFR mutation subtype

SUBMITTER: Lei Y 

PROVIDER: S-EPMC8899028 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature