Urinary exosome-based androgen receptor-variant 7 detection in metastatic castration-resistant prostate cancer patients.

ABSTRACT:

Background

Androgen receptor variant 7 (AR-V7) detection provides important information for the clinical management of abiraterone in metastatic castration-resistant prostate cancer (mCRPC). We performed a non-invasive urine-derived exosomal AR-V7 analysis of mCRPC patients.

Methods

A total of 34 mCRPC patients were recruited including 16 patients treated with abiraterone (ABI) with stable prostate-specific antigen (PSA)/radiograph response (the ABI-Sta group) and 18 were resistant to abiraterone (the ABI-Res group). Urine was collected from patients and healthy control patients for the analysis. Exosomal ribonucleic acid was isolated from urine. Urinary exosome-based androgen receptor-variant 7 was detected by quantitative real-time polymerase chain reaction assay. Characte

SUBMITTER: Wang C 

PROVIDER: S-EPMC8899142 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature