Initial gonadotropin levels and sperm parameters differentiate the response to clomiphene citrate in subfertile men.

ABSTRACT:

Background

Efficacy of clomiphene citrate (CC) in the treatment of male subfertility remains unclear, with inconsistent results in the literature and limited guidance from professional organizations. We sought to stratify the response to clomiphene in men based on their initial gonadotropins and semen parameters.

Methods

We conducted a retrospective analysis of 234 patients from an academic center who took CC for subfertility. Patients with pre-treatment and 3 months follow-up total testosterone (TT) and semen analyses were included. Patients with previous hormone therapy, genitourinary surgery, prior success in conceiving pregnancy, or only one semen analysis were excluded. Primary outcomes were magnitudes of improvement in TT and semen parameters at 3 months. Student's

SUBMITTER: Jiang T 

PROVIDER: S-EPMC8899152 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature