STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2 in osteoporosis.

ABSTRACT: Osteoporosis is one of the leading forms of systemic diseases related to bone metabolism in the world. STARD3 N-terminal like (STARD3NL) showed robust association with osteoporosis-related traits. Yet, the molecular functional mechanisms of STARD3NL in osteoblasts is still obscure. In this study, we demonstrated a high level of STARD3NL expression in the bone tissues from the patients with low bone mass and ovariectomized (OVX)-induced osteoporotic mice. We identified Stard3nl as a potent factor that negatively and positively regulates osteoblast differentiation and cell proliferation, respectively. Furthermore, inhibition of Stard3nl induced β-catenin gene expression and the nuclear translocation of β-catenin, as well as Wnt signalling activities, contributing to the activation of Wnt/β-c

SUBMITTER: Xu Y 

PROVIDER: S-EPMC8899174 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature