Inadequate Bioavailability of Intramuscular Epinephrine in a Neonatal Asphyxia Model.

ABSTRACT:

Background

Over half a million newborn deaths are attributed to intrapartum related events annually, the majority of which occur in low resource settings. While progress has been made in reducing the burden of asphyxia, novel approaches may need to be considered to further decrease rates of newborn mortality. Administration of intravenous, intraosseous or endotracheal epinephrine is recommended by the Newborn Resuscitation Program (NRP) with sustained bradycardia at birth. However, delivery by these routes requires both advanced skills and specialized equipment. Intramuscular (IM) epinephrine may represent a simple, low cost and highly accessible alternative for consideration in the care of infants compromised at birth. At present, the bioavailability of IM epinephrine in asphyxia

SUBMITTER: Berkelhamer SK 

PROVIDER: S-EPMC8899212 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature