Dataset Information

The Immediate Effect of COVID-19 Vaccination on Anticoagulation Control in Patients Using Vitamin K Antagonists.

ABSTRACT:

Background

In January 2021, the Dutch vaccination program against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was started. Clinical studies have shown that systemic reactions occur in up to 50% of vaccine recipients. Therefore, COVID-19 vaccination could affect anticoagulation control, potentially leading to an increased risk of thrombotic events and bleeding complications.

Aims

This article investigates whether the BNT162b2 vaccine affects anticoagulation control in outpatients using vitamin K antagonists (VKAs).

Methods

A case-crossover study was performed in a cohort of outpatient VKA users from four Dutch anticoagulation clinics who received a BNT162b2 vaccine. International normalized ratio (INR) results and VKA dosages before the first vaccination, the reference period, were compared with those after the first and second vaccination.

Results

A total of 3,148 outpatient VKA users were included, with a mean age (standard deviation) of 86.7 (8.7) years, of whom 43.8% were male, 67.0% used acenocoumarol, and 33.0% phenprocoumon. We observed a decrease of 8.9% of INRs within range in the standard intensity group (target INR 2.0-3.0). There was both an increased risk of supratherapeutic (odds ratio [OR] = 1.34 [95% confidence interval [CI] 1.08-1.67]) and subtherapeutic levels (OR = 1.40 [95% CI 1.08-1.83]) after first vaccination. In the high-intensity group (target INR 2.5-3.5), the risk of a supratherapeutic INR was 2.3 times higher after first vaccination (OR = 2.29 [95% CI 1.22-4.28]) and 3.3 times higher after second vaccination (OR = 3.25 [95% CI 1.06-9.97]).

Conclusion

BNT162b2 was associated with an immediate negative effect on anticoagulation control in patients treated with VKAs, so it is advisable to monitor the INR shortly after vaccination, even in stable patients.

SUBMITTER: Visser C

PROVIDER: S-EPMC8899332 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Publications

The Immediate Effect of COVID-19 Vaccination on Anticoagulation Control in Patients Using Vitamin K Antagonists.

Visser Chantal C Biedermann Joseph S JS Nierman Melchior C MC van der Meer Felix J M FJM Gulpen Anouk J W AJW Moors Yvonne C F YCF Cannegieter Suzanne C SC Lijfering Willem M WM Kruip Marieke J H A MJHA

Thrombosis and haemostasis 20220304 3

<h4>Background</h4> In January 2021, the Dutch vaccination program against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was started. Clinical studies have shown that systemic reactions occur in up to 50% of vaccine recipients. Therefore, COVID-19 vaccination could affect anticoagulation control, potentially leading to an increased risk of thrombotic events and bleeding complications.<h4>Aims</h4> This article investigates whether the BNT162b2 vaccine affects anticoagulation contr ...[more]

PMID: 35245945

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Project description:Healthcare professionals play a pivotal role in protecting and saving the lives of general people. As health workers are more likely to be infected with COVID-19, it is inevitable to safeguard them through vaccination in advance to continue healthcare services. Hence the study aimed to explore the infection and vaccination status along with immediate health consequences among these frontiers. This was a cross-sectional, web-delivered study conducted among the 300 healthcare frontiers working at COVID-19 dedicated hospitals in eight divisions of Bangladesh. The study questionnaire encompasses infection, vaccination status with dose information, and demographical and organizational information among the respondents. A multivariate logistic regression model and Chi-square test was used for the analytical exploration. Adjusted and Unadjusted Odds Ratio with a 95% confidence interval was calculated for the specified setting indicators. The study revealed that 49% of all respondents tested positive whereas 98% of them were found vaccinated of which mostly (52.3%) had their 2nddoses and 68.7% faced immediate health consequences for having the vaccination. As predictor for COVID-19 infection status, young and senior adult group (30-39 years: AOR = 2.01/0.03; 95% CI: 1.08-3.76; >50 years: AOR = 4.36/0.01; 95% CI: 1.65-11.55) and respondents who received Sinopharm as their vaccine found to have more significant positive infection history. The predictors regarding experiencing immediate health effects after vaccination, surprisingly female (AOR = 3.31/0.01; 95% CI: 1.82-6.04) health professionals of the capital city (AOR = 1.91/0.03; 95% CI: 1.06-3.46) were observed to have health consequences on vaccination. As the older female group (>50 years) in the nursing profession was found more infected with COVID-19 and a significant number of health professionals especially the age group (30-39 years) in the nursing profession experienced immediate health effects of COVID-19 vaccination, implementation of specific strategies and policies are needed to ensure the safety precaution and effective vaccination among the health professionals of Bangladesh.

Dataset Information

The Immediate Effect of COVID-19 Vaccination on Anticoagulation Control in Patients Using Vitamin K Antagonists.

Background

Aims

Methods

Results

Conclusion

Publications

The Immediate Effect of COVID-19 Vaccination on Anticoagulation Control in Patients Using Vitamin K Antagonists.

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