High expression of SEZ6L2 as an independent prognostic Indicator in thyroid carcinoma.

ABSTRACT:

Background

Seizure-related 6 homolog (mouse)-like 2 (SEZ6L2) is a type 1 transmembrane protein that is primarily expressed in the brain . In recent reports, SEZ6L2 has been found to be overexpressed in some cancers and can drive the progression of tumors. However, its function and mechanism in thyroid cancer remain unclear.

Methods

In this article ,we searched for the SEZ6L2 expressions in Pan-cancer on TCGA (The Cancer Genome Atlas) and evaluated these data using the TIMER2 method. Then, the immunohistochemical score (IHC score) of SEZ6L2 in cancer tissue was collected in human protein mapping (HPA) data. And we used CIBERSORT to assess the association between the levels of SEZ6L2 expression and the number of various immune cells in papill

SUBMITTER: Luo X 

PROVIDER: S-EPMC8899425 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature