Association Between Atopic Dermatitis, Asthma, and Serum Lipids: A UK Biobank Based Observational Study and Mendelian Randomization Analysis.

ABSTRACT:

Background

Both atopic diseases and dysregulation of serum lipids (SLs) add to significant health burden, but evidences about their association are inconsistent.

Objective

This work is to evaluate the association between asthma/atopic dermatitis (AD) and SLs and investigate the potential causal relationship.

Methods

A large-scale cross-sectional study based on the UK Biobank (UKB) and then examined the casual relationships between SLs with asthma/AD based on a Mendelian randomization (MR) analysis.

Results

A total of 502,505 participants were included in analysis. After full adjustment, AD was associated with lower TG (β = -0.006; 95%CI, -0.010 to -0.002; P = 0.006), lower LDL (β = -0.004; 95%CI, -0.006 to -0.002, P < 0.001), and lower TC (β = -0.

SUBMITTER: Tang Z 

PROVIDER: S-EPMC8899503 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature