Impacts and mechanisms of alternative mRNA splicing in cancer metabolism, immune response, and therapeutics.

ABSTRACT: Alternative pre-mRNA splicing (AS) provides the potential to produce diversity at RNA and protein levels. Disruptions in the regulation of pre-mRNA splicing can lead to diseases. With the development of transcriptome and genome sequencing technology, increasing diseases have been identified to be associated with abnormal splicing of mRNAs. In tumors, abnormal alternative splicing frequently plays critical roles in cancer pathogenesis and may be considered as new biomarkers and therapeutic targets for cancer intervention. Metabolic abnormalities and immune disorders are important hallmarks of cancer. AS produces multiple different isoforms and diversifies protein expression, which is utilized by the immune and metabolic reprogramming systems to expand gene functions. The abnormal splicing e

SUBMITTER: Peng Q 

PROVIDER: S-EPMC8899522 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature