Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development.

ABSTRACT: The spatial organization of immune cells within the tumor microenvironment (TME) largely determines the anti-tumor immunity and also highly predicts tumor progression and therapeutic response. Tim-3 is a well-accepted immune checkpoint and plays multifaceted immunoregulatory roles via interaction with distinct Tim-3 ligands (Tim-3L), showing great potential as an immunotherapy target. However, the cell sociology mediated by Tim-3/Tim-3L and their contribution to tumor development remains elusive. Here, we analyzed the spatial distribution of Tim-3/Tim-3L in TME using multiplex fluorescence staining and revealed that despite the increased Tim-3 expression in various tumor-infiltrated lymphocytes, Tim-3⁺CD4⁺ cells were more accumulated in parenchymal/tumor region compar

SUBMITTER: Wang T 

PROVIDER: S-EPMC8899527 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature