Clinical Correlates Identify ProBDNF and Thrombo-Inflammatory Markers as Key Predictors of Circulating p75^NTR Extracellular Domain Levels in Older Adults.

ABSTRACT: The p75^NTR receptor binds all neurotrophins and is mostly known for its role in neuronal survival and apoptosis. Recently, the extracellular domain (ECD) of p75^NTR has been reported in plasma, its levels being dysregulated in numerous neurological diseases. However, the factors associated with p75^NTR ECD levels remain unknown. We investigated clinical correlates of plasma p75^NTR ECD levels in older adults without clinically manifested neurological disorders. Circulating p75^NTR levels were measured by enzyme-linked immunosorbent assay in plasma obtained from participants in the BEL-AGE cohort (n = 1,280). Determinants of plasma p75^NTR ECD levels were explored using linear and non-linear statistical models. Plasma p75

SUBMITTER: Fleury S 

PROVIDER: S-EPMC8899540 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature