Multi-modal molecular imaging maps the correlation between tumor microenvironments and nanomedicine distribution.

ABSTRACT: Gaining insight into the heterogeneity of nanoparticle drug distribution within tumors would improve both design and clinical translation of nanomedicines. There is little data showing the spatio-temporal behavior of nanomedicines in tissues as current methods are not able to provide a comprehensive view of the nanomedicine distribution, released drug or its effects in the context of a complex tissue microenvironment. Methods: A new experimental approach which integrates the molecular imaging and bioanalytical technologies MSI and IMC was developed to determine the biodistribution of total drug and drug metabolite delivered via PLA-PEG nanoparticles and to overlay this with imaging of the nanomedicine in the context of detailed tumor microenvironment markers. This was used to assess

SUBMITTER: Strittmatter N 

PROVIDER: S-EPMC8899579 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature