Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model.

ABSTRACT: Rationale: The blood-brain barrier (BBB) while functioning as a gatekeeper of the brain, impedes cerebral drug delivery. An emerging technology to overcome this limitation is focused ultrasound (FUS). When FUS interacts with intravenously injected microbubbles (FUS^+MB), the BBB opens, transiently allowing the access of therapeutic agents into the brain. However, the ultrasound parameters need to be tightly tuned: when the acoustic pressure is too low there is no opening, and when it is too high, tissue damage can occur. We therefore asked whether barrier permeability can be increased by combining FUS^+MB with a second modality such that in a clinical setting lower acoustic pressures could be used. Methods: Given that FUS^+MB achieves BBB opening

SUBMITTER: Chen L 

PROVIDER: S-EPMC8899584 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature