Exchange of cellular components between platelets and tumor cells: impact on tumor cells behavior.

ABSTRACT: Background: Platelets are active players in tumorigenesis, although the exact interactive mechanisms and their direct impact on tumor cells remain largely unknown. Methods: Bidirectional transference of lipids, proteins and RNA between platelets and tumor cells and its impact on tumor cell behavior and tumor process are analyzed in this work. Phenotypic, genetic and functional modifications induced by platelets were analyzed both in tumor cell lines and in circulating tumor cells (CTCs). Results: Data from these assays showed that platelets transferred structural components to tumor cells with higher efficiency than tumor cells to platelets (p = 0.001). This biological interplay occurred by direct contact, internalization or via extracellular vesicles. As a result, tum

SUBMITTER: Rodriguez-Martinez A 

PROVIDER: S-EPMC8899588 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature