New Druggable Targets for Rheumatoid Arthritis Based on Insights From Synovial Biology.

ABSTRACT: Rheumatoid arthritis (RA) is a multifactorial autoimmune disease characterized by chronic inflammation and destruction of multiple small joints which may lead to systemic complications. Altered immunity via pathogenic autoantibodies pre-date clinical symptom development by several years. Incompletely understood range of mechanisms trigger joint-homing, leading to clinically evident articular disease. Advances in therapeutic approaches and understanding pathogenesis have improved prognosis and likely remission. However, partial/non-response to conventional and biologic therapies witnessed in a subset of patients highlights the need for new therapeutics. It is now evident that joint disease chronicity stems from recalcitrant inflammatory synovial environment, majorly maintained by epi

SUBMITTER: Sandhu G 

PROVIDER: S-EPMC8899708 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature