Combined screening analysis of aberrantly methylated-differentially expressed genes and pathways in hepatocellular carcinoma.

ABSTRACT:

Background

Methylation plays an important role in hepatocellular carcinoma (HCC) by altering the expression of key genes. The aim of this study was to screen the aberrantly methylated-differentially expressed genes (DEGs) in HCC and elucidate their underlying molecular mechanism.

Methods

Gene expression microarrays (GSE101685) and gene methylation microarrays (GSE44909) were selected. DEGs and differentially methylated genes (DMGs) were screened. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed using the Database for Annotation, Visualization, and Integrated discovery (DAVID). The Search Tool for the Retrieval of Interacting Genes (STRING) database was used to analyze the functional protein-protein interaction (PPI) network. Molec

SUBMITTER: Cao J 

PROVIDER: S-EPMC8899745 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature